Most recent articles first. Steve is a Silicon Valley entrepreneur and philanthropist who founded the COVID-19 Early Treatment Fund (CETF) at the beginning of the pandemic. Doctors are afraid that even with a 37-year safety record of this drug, that something will go terribly wrong and they will be blamed. Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI), a class of anti-depressants, mostly prescribed for people suffering from an obsessive-compulsive disorder. In-patient use. That receptor also helps regulate the body's . People who report not tolerating the drug are typically prescribed too high a dose. JAMA systematic review and meta analysis It doesnt get any better than this. Fluvoxamine was reportedly added to just 2 practice guidelines (Ontario and Johns Hopkins). Doctors wait for government permission (EUA or added to the NIH guidelines) before using a drug. Im not going to make the same mistake again.. But they dont want their names used. @stkirsch. It was tested in coronavirus patients because fluvoxamine has very strong anti-inflammatory properties. I only know of a few doctors who prescribe this off-label, all with 100% success rates. , a non-profit known as the nations drug pricing watchdog, did a review of the evidence and determined that fluvoxamine evidence is superior to Molnupiravir. We don't know why the NIH panel is ignoring fluvoxamine and we aren't allowed to find out. Repurposed drugs are safer and more effective than the current vaccines. Mar. This document is a collection of evidence that highlights the glaring errors in our pandemic response. FDA official fluvoxamine rejection. Is that really true? Reason is the hospital gets release from liability if they follow NIH guidelines. Thirty minutes past the end of our scheduled time, he dropped his phone in the cupholder of his Tesla so that he could keep talking while he ran an errand. Kirsch, though, often relies on the heartstrings to smooth over a lack of data. Doctors who have used fluvoxamine in the US and other countries swear by it. Skirsch.io Steve Kirsch Home page Fluvoxamine, COVID, pandemic, . See this Wall Street Journal op-ed. We don't know why the NIH panel is ignoring fluvoxamine and we aren't allowed to find out. Last Checked: 03/02/2023. We dont want to feed the anti-vaccine trolls, so we actively suppress clear scientific data. So check the side-effects list to be familiar with which side-effects are associated with which drug so if you have a side-effect, youll know which drug to reduce or eliminate. I mean, he really, truly has a heart of gold, Char told me. The results would, eventually, set Kirsch on a collision course with the scientific establishment. I agreed to do it partially because I respect Bob [Siliciano] so much, and partially because I thought the concept was excellent, said former board member Doug Richman, a prominent HIV drug researcher at the University of California San Diego and former member of the funds scientific advisory board. I have all of these on hand and I load up on vitamin D3 every day. May 16, 2022. This is the gold standard of evidence based medicine, Article about the fluvoxamine rejection (The Verge). Can I see your risk-benefit analysis?. Fluvoxamine, Proxalutamide, and Ivermectin: 100% success I'm very bullish on two drug combos since it is rare for Read More The best COVID treatments for hospitalized patients Seven treatments for hospitalized COVID patients with very high success rates. He has a BS/MS in Electrical Engineering and Computer Science from MIT. In June, after CETFs advisory board resigned, Kirsch did a Facebook Live video with Zelenko and celebrity rehab coach Dr. Drew. 1991-1992 to 7.1% in 2001-2002. 1:49 If you start 5 days after symptoms, all bets are off. The Wall Street Journal thinks it should be used (and that the NIH is wrong for waiting for more clinical trials). Dr. Eric Lenze: So the results were really pretty. CETF founder Steve Kirsch accepted an invitation to discuss the findings on a weekly . The medical community did nothing (with a few exceptions like Dr. Seftel). This give another 50% of benefit. But they will refuse to give it to you even after being proven in a Phase 3 trial that was approved by the WHO. are all super cheap, effective, and available without a prescription. If you cant lay off the java, then try fluoxetine (Prozac). 22, 2021, 9:00 a.m. Steve Kirsch , a former tech entrepreneur who earned a fortune worth up to $300 million, has been showcased on TrialSite a few times for his activity supporting the clinical development of repurposed drugs for COVID-19 treatments. You can experience serious side effects if you do not pay attention to interactions such as if you are currently on another SSRI of a different type. His appearance on an episode of anti-covid-vaccine, pro-ivermectin pundit Bret Weinsteins DarkHorse podcast, alongside Robert Malone, a prominent source of vaccine misinformation, introduced Kirsch to followers of the intellectual dark web, who have since embraced him as a fellow truth-teller. Another CETF grant, though, yielded far more exciting results. But the whole process has gone too slowly for Kirsch. If you take fluvoxamine, please avoid caffeine while on the drug. We could have saved a lot of lives. Dose escalation studies in lupus patients and in rheumatoid arthritis patients established that 800 mg per day for life and 1,200 mg per day for 6 weeks are extremely well-tolerated. This was shown to be very tolerable (no side effects in 99% of patients) and extremely effective (no hospitalizations and death if you start it ASAP after first symptoms). It was approved by the FDA in 1994 and has been used in millions of patients worldwide. . Los Altos Hills resident Steve Kirsch funded research into the drug fluvoxamine as a treatment for COVID-19. Doctors who are most familiar with the drug would prescribe it to their patients. If you cant get a prescription for COVID, then perhaps you have OCD? When you need to characterize me, you need to say that Steve Kirsch doesnt go with majority votes on interpreting data, he told me when I asked about his views on ivermectin, which he insists is a silver bullet against covid. It is in a class of drugs known as selective serotonin-reuptake inhibitors (SSRIs), but unlike other SSRIs, fluvoxamine interacts strongly with a protein called the sigma-1 receptor. Kirsch is a serial entrepreneur who has spent decades pitching the next big thing, whether optical mice (Mouse Systems), document processing (FrameMaker), search engines (Infoseek), digital. But even that didnt last long. To date, the #1 drug with the most evidence to make a significant difference, without any doubt, is fluvoxamine. Hes probably the closest thing Kirsch has to a nemesis, regularly disputing his assertions in blog posts and private email exchanges with Kirsch and his friends. He may not be a good scientist, but hes smart, says WVUs Feinberg. If it isn't fluvoxamine preventing hospitalization and long-haul COVID, then if you find what it is, you win. Another is to identify an asteroid that is going to hit the planet.. Kirsch is a serial entrepreneur who has spent decades pitching the next big thing, whether optical mice (Mouse Systems), document processing (FrameMaker), search engines (Infoseek), digital. In October, the group reported that, while a few patients in the placebo group ended up in the hospital, none of the patients receiving fluvoxamine got sick enough to go. Fluvoxamine is way better than Molnupiravir, but the NIH doesnt approve drugs on effectiveness. The evidence is solid. The board members I spoke to say they refused to publicly promote any drugs for off-label use and tried to explain to Kirsch that its incredibly common for exciting results from small trials to disappear in larger ones. The infectious disease scientists lied to me. The combined p value of the two studies is <.0001. Today, we are letting people drown and we are not even telling them there is a life preserver they can ask for today with compelling evidence that is under consideration by the life preserver safety group. Links to evidence about fluvoxamine including the public data repository. It is not unusual to be wary of developing science, or wrong to be skeptical of pharmaceutical companies. The External Medicine Podcast - Fluvoxamine as a potential treatment for COVID-19: An Interview with Steve Kirsch. Instead, the government prefers to fund and promote new, proprietary drugs and vaccines, he says. He started 7 high tech companies, two with billion dollar market caps. No long haul symptoms if you start the drug ASAP after first symptoms. Both drugs have compelling data that is hard to explain if the drug doesn't work. skirsch.io. The next major effect is that that fluvoxamine activates the sigma-1 receptor. That covers almost 150,000 of them, which happened before vaccinations began. Jeffrey Glenn, an infectious disease professor at Stanford University, calls the inaction on the current evidence on the table "criminal.". One user reported dilated pupils and increased heart rate (which could be nerves about the dilated pupils). He was recently featured on 60 Minutes which highlighted his . My website. Fluvoxamine was reportedly added to just 2 practice guidelines (. Flavio Cadegiani and Steve Kirsch's studies didn't make the cut. And, according to three members of CETF's scientific advisory board, he put pressure on them to promote fluvoxamine for clinical use without conclusive data that it worked for . Three of the four outpatient trials have been reported out: all were successful. One of the first CETF grants was to investigate the antimalarial hydroxychloroquine. I fully expected both organizations to do absolutely nothing. [https://www.quora.com/What-is-the-current-treatment-for-Covid-19/answer/, The most urgent need in the country right now is to reduce. One Silicon Valley entrepreneur thought he could beat the odds. From the French observational data (see the very last page), it appears that the biggest effect is limiting serotonin release (any SSRI will do that). That way you can start immediately. Always be self aware when using fluvoxamine. All have had a 100% success record in keeping their patients out of the hospital. My experience is very typical. To vet proposals, he recruited a powerhouse advisory board of prominent biologists, drug developers, and clinical researchers, led by world-renowned drug researcher Robert Siliciano of Johns Hopkins. It was completed in August. . On January 22, 2021, thirty key opinion leaders (KOL) from NIH, CDC, and leading academic institutions met to review the evidence for using fluvoxamine for treating COVID. On his blog, Covid-19 Data Science, he has extensivelyand mercilesslyunpacked Kirschs evidence for the vaccine death claims. MD, MPH; Steven C. Marcus, PhD. With little government funding available for such work, Kirsch founded the Covid-19 Early Treatment Fund (CETF), putting in $1 million of his own money and bringing in donations from Silicon Valley luminaries: the CETF website lists the foundations of Marc Benioff and Elon Musk as donors. It is very safe: There is no evidence fluvoxamine is harmful and led to a worse outcome. Fluvoxamine has a 40 year safety track record. Kirsch and his wife, Michele, fund a charitable foundation, which by 2007 had given $75 million to different causes. Fluoxetine is just as effective. Steve Kirsch is baffled. Steve Kirsch Nov 5, 2021 145 92 Here are the key things you should know about fluvoxamine for COVID: It works. Items included in the Television News search service. The NIH picks the drug that makes the most money for the drug companies regardless of long-term safety Molnupiravir! When the pandemic started, he created the COVID-19 Early Treatment Fund (CETF) to fund researchers working on repurposed drugs including fluvoxamine which reduces death from COVID by a factor of 12. The repository goes over the prescribing guidelines, contraindications, and describes the effect on caffeine consumption while on drug (basically you want to avoid caffeine while on the drug). . See more below. Telling the truth, he tweeted. Ivermectin has been falsely promoted as a covid treatmentbut for those who use the drug legitimately, seeing it become a piece of anti-vaccine misinformation is disconcerting. Also, this drug is only prescribed by psychiatrists so most doctors have no experience whatsoever with the drug. Nobody in the medical community is speaking out about how hypocritical the medical community is for ignoring the positive Phase 3 trial results and instead following whatever the NIH or FDA says. No more. Ive used it personally at 50mg twice a day and experience no adverse events at all. Steve calls himself a "medical philanthropist" who says "the most important thing to me is saving lives." In . None of this would really matter if Kirschs views on vaccinations were private, or shared with a limited audience. All can merit a fluvoxamine prescription based on traditional diagnoses. Fluvoxamine is the poster child of the COVID-19 Early Treatment Fund (CETF). Once the Phase 2 result came out, it should have been embraced by doctors. 19 In addition, several . Quick Summary . Other drugs in this class include Prozac (fluoxetine), Zoloft (sertraline) and Paxil (paroxetine). The Lancet paper showed that if you were treated early enough and took the drug as prescribed (it only works if you take it), it was shown to reduce your chance of death by 12X making it far more effective than any other drug for COVID. But the potential upsides. Molnupiravir followed patients for only 30 days because they know the drug is dangerous. Its all about NIH saying it is OK. . Sage Hana. I've asked people, "there's a lot of evidence here it's not just a small phase 2 RCT. No more. In the second trial, it was shown to be 100% effective in long-haul COVID symptoms: None of the treated patients had any long-haul symptoms after 2 weeks compared to 60% of untreated patients having 1 or more of the 15 long-haul symptoms after two weeks, and 29% having 4 of more of the long haul symptoms after 2 weeks. We look for advances that will have a big impact on our lives and break down why they matter. It is an amazing drug and is a very simple safe way to avoid long-haul COVID symptoms. They rejected the drug for insufficient evidence just like they always do for ivermectin. Steve and CETF funded the research that showed promising results of fluvoxamine as an early treatment of COVID-19. Do they sell it anywhere? But Kirsch is also motivated by an unsatisfied competitive streak. Steven Todd Kirsch is an American entrepreneur. I learned this the hard way. In other cases, stop cold turkey. It should be crystal clear to everyone that the current CDC guidelines for treating COVID aren't working. But the best way to help people is through rigorous trials that show what drugs help which people, and at what doses and timesnot by basing entire protocols on incredibly limited evidence. Kirsch: Yes, but you could easily watch that 60 Minutes story and believe that we need more data before people should start using fluvoxamine. including the very promising Fluvoxamine. David Boulware, a researcher at the University of Minnesota, received $125,000 to test the drug against covid. Added to FLCCC protocols and Fareed-Tyson protocol among others. How I recommend people treat COVID and the fascinating backstory of how fluvoxamine was discovered. . To date, we have heard nothing suggesting the drug doesn't work or could be harmful. Enter the email address you signed up with and we'll email you a reset link. Online. In May, all 12 members of CETFs scientific advisory board resigned, citing his alarming dangerous claims and erratic behavior. With cases spiking, the Los Angeles area banned gatherings. If you do have a side-effect, it is usually mild nausea which goes away when you stop taking the drug. Infoseek lost out to Yahoo; it had a chance to grow bigger, but it didn't. Seftel was able to duplicate the 100% protection from hospitalization and death in the treatment group, vs. a 12.5% hospitalization/death rate for the No treatment group. The drug was widely prescribed as a covid treatment for much of 2020, based on anecdotes and flawed studies. People are dying because of physician fear of a new treatment with a 100% success rate and a solid mechanism of action. Expect similar things to happen when Eiger applies for an EUA for interferon lambda, a drug with a 89% efficacy in phase 3 trials. If you start later, doctors use higher dosages and compliance becomes a bigger problem. The alarming article cited the claims of two anti-vaxxers, Steve Kirsch and Dr. Robert Malone. This drug can save your life but you have to ask for it! Pretty much nothing changed when the Phase 3 trial confirmed fluvoxamine worked. At the dosing for COVID (50mg BID x 14 days), there is a 1% chance of mild-nausea and because the dose is so low and the time it is taken is so short, and there are no psychotropic effects (which require more than 3 weeks of use; the psychotropic effects non-existent if you don't have depression or an anxiety disorder in the first place). Di scl ai mer: T he vi ews expressed i n t hi s art i cl e are my own personal opi ni on based on my 1, 000+ hour st udy of cut t i ng edge . The documents in the data room discuss all eight (you'll need access to the restricted area to see the presentation on all 8). The drugs mechanisms of action were explained to the KOL panel which voted 2>1 in favor of fluvoxamine. In severe cases, it takes longer. If there is a better drug on the table today than fluvoxamine, the NIH panel should put that one on the guidelines. . These people never called the researchers whose trials they claimed showed no effect. Note that some of these articles are inaccurate. Most doctors wont use it until NIH greenlights it, no matter what the science says. Almost 2.5 million people signed up to Dr. B with the promise of getting leftover vaccines. Some are views most scientists think are wrong. Get your prescription in advance of getting COVID. By the beginning of September, he was no longer the companys CEO, replaced by his co-founder, Marten Nelson. Skirsch.io site visitors volume is 1,957 unique day-to-day guests and their 3,914 pageviews. But fear of trying something new prevents any doctor from giving this drug a try. Steve put in $1MM of his own money and . There are reports of people who cant tolerate the drug, but they stop using it and nothing bad happened. Some people report mild nausea while on the drug (stops when stop the drug). Fluvoxamine is an inexpensive drug that has been in use for 37 years and has been used by an estimated 10 million people. reach out to us at There are 4 outpatient studies that have been done (2 at WashU (see. ). In three phone conversations, as well as dozens of emails, his responses to questions about claims in this story were imprecise or constantly changing. In that same IEEE Spectrum story about his then-new startup, Propel Software, he said he felt successful, but not famous. Thanks for working tirelessly to help others. They were giving covid patients the antidepressant fluvoxamine as soon as possible after diagnosis, based on anecdotes about the drug limiting the runaway immune response that causes many severe symptoms. We are ignoring the advice of the KOL group and doing nothing. He considers himself an expert in something that he doesnt have training or experience in, and hes not following scientific methods to assess data.. It is about following orders and making money for the drug companies and protecting the doctor from liability and losing his medical license. It does not matter how many lives will be saved. The NIH wrote a bullshit rejection because the FDA told them not to approve it. Everyone says "we need more data" to show fluvoxamine works for COVID. ICER Publishes Final Evidence Report and Policy Recommendations on Outpatient Treatments for COVID-19 - ICER. How I recommend people treat COVID and the fascinating backstory of how fluvoxamine was discovered. There are at least eight mechanisms of action that we think contribute to the effectiveness of this drug. Ive talked to doctors who are extremely familiar with the drug and all the trial results and they would prescribe it to their patients. So there were too few events in the placebo group and they werent recruiting fast enough. The paramedics will think you are on drugs. Other SSRIs work as well, but fluvoxamine activates the Sigma-1 receptor the most of the SSRIs which is why it was chosen. Thats what creates some of these heroes.. Zero. It used to be that a Phase 3 study would do it. He has been a medical philanthropist for more than 20 years. His foundation shifted focus to one goalcuring Steve Kirschby supporting one of the few scientists looking at the disease. The reason that it isnt used is because the medical community ignores evidence-based medicine principles. I couldnt tell I was on the drug. Why fluvoxamine isnt used. And not zero., Kirsch immediately forwarded the exchange to me and, I suspect, other journalists. In September, Kirsch emailed Morris asking him to estimate the maximum number of deaths caused by vaccines. In some cases, youd want to taper down the dosage. Hes spending his own money to do what he thinks is right. We now have a viable solution to reduce COVID hospitalization and mortality; Say you just got diagnosed with COVID. Who knows, Morris replied. Soon after his appearance on the DarkHorse podcast, several partners of his most recent startup, M10, expressed concerns about the increasing extremism of Kirschs vaccine views. Compulsive hand washing? That is when the phase 2 results were published. We should be making decisions now based on the evidence on the table today. But they will refuse to give it to you even after being proven in a Phase 3 trial that was approved by the WHO. After publication of the recommendation in December 2021, the NIH did absolutely nothing change their recommendation. I took it myself at that dosage and noticed zero side effects. Government agencies are ignoring the science. All can merit a fluvoxamine prescription based on traditional diagnoses. Why not fluvoxamine? There are two ways Ive discovered that I may be able to save the world, he told an IEEE Spectrum reporter in 2000. Yes, these were successes, but the successes could have been bigger if we had really paid attention to marketing. People who report not tolerating the drug are typically prescribed too high a dose. The data we have today with just 2 clinical trials (RCT and confirmatory RWE) is compelling. Or just depression about the vaccine mandates? Yeah, its possible, he told mehe also says that he has regularly seen Kirsch manipulate evidence so that it seems to support claims that are, in reality, baseless. Author Affiliations Article Information. After several failed attempts to stop the progression of his disease, he designed his own protocol for chemotherapy and doctor-shopped to find an oncologist who would give it to him. It was so bad you couldnt even see the babys body through all the blood, Kirsch said. My experience is very typical. Steve wanted to say, Look, Ive got all these famous [infectious disease] docs and researchers, and they all say give fluvoxamine a chance, Judith Feinberg, one of the former CETF advisory board members and vice chair of research at the West Virginia University School of Medicine, told me. Seftel used a 50mg BID dosing for 14 days which was one third of the max dose used in the Lenze study. If you start 5 days after symptoms, all bets are off. The Lancet paper showed that if you were treated early enough and took the drug as prescribed (it only works if you take it), it was shown to reduce your chance of death by 12X making it far more effective than any other drug for COVID. If the drug is started right after symptoms, weve seen 100% prevention in hospitalization. Some countries dont have fluvoxamine so this is the alternative. Think about it Molnupiravir has a 50% risk reduction whereas fluvxoamine is over 90%. Stopping the meds will return you to your normal self. Ivermectin has a very high quality systematic review, the highest possible level in Evidence Based Medicine. Summary of key evidence. As of January 18, 2021, the CDC estimates that 90,000 Americans will die from COVID in just the next 3 weeks. I fixed the link to the fluvoxamine article. Steve Kirsch. . There were IRB rules that required the 65 patients to be listed in the diagrams and charts. Dr. Seftel's paper has been accepted for publication and will appear in OFID in early February. P-value was 10^-14 on that study (done by Dr. Seftel). I have never heard of a case it didn't work. Then he hosted a superspreader event. . Here is the latest version. Kirsch, despite having direct access to the actual trial runner, eventually became convinced a correct interpretation of the data would show that hydroxychloroquine worked. BOMBSHELL: Top biostats professor admits we have NO CLUE # of people KILLED by COVID vaccines, he wrote. If you are experiencing any odd adverse reactions, youll need to consult with your doctor ASAP. Its whether Merck can make a killing that matters. I couldnt tell I was on the drug. . thinks it should be used (and that the NIH is wrong for waiting for more clinical trials). The FDA approved Molnupiravir which was less effective. Discover special offers, top stories, This alone will give roughly a 50% effect size and explains why all of the the SSRIs are effective including those that do not activate the Sigma1 receptor (e.g., Paroxetine). Share this post. Its motivated out of his sense of keeping people safe and advancing health care.. There is no evidence fluvoxamine is harmful and led to a worse outcome. All the medical journals refused to publish the meeting notes (rejected by 6 journals). I must admit that this is an anniversary that snuck Steve Kirsch, current director of the Covid 19 Early Treatment fund is an MIT alumni who has made a career as a tech entrepreneur. That was a big mistake because the original paper contained text related to earlier studies and the editors chopped it out. While YouTube has repeatedly taken down the full video of the DarkHorse episode, various clips have been watched over 4 million times, and the full audio remains available on Spotify. This is quite stunning because the PK of the drug done at the Gates Foundation shows it only reaches 50% of the final concentration after 3 days. I didnt intend to spend a lot of time on Steve in particular, but that video was so influential.. When I asked him why so many experts in the field disagreed with him, he alleged there were effortseither malicious or negligentto suppress evidence of cheap, effective covid treatments. Also, for people who cant tolerate fluvoxamine for whatever reason (nausea, jittery, etc), this is the alternative. Here's why. What has alarmed many of the scientists associated with CETF, though, are Kirschs reactions to the work hes fundedboth successes and failures. Kirsch said that his attempts to promote fluvoxamine are being curtailed. ALWAYS check with your doctor and report any medications you are taking before or plan to take after you start taking fluvoxamine. Article about the rejection (Stat News) Article about the fluvoxamine rejection (The Verge) NIH is still unsure whether fluvoxamine should be used to treat COVID (article I did after the TOGETHER trial).
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